(Transparency statement here: I used my handy dandy AI assistant to do the legwork and pull up the info for this article. When I checked out the links, they seem to be provided by the testing companies themselves so take everything here with a grain of salt! Be sure to check out the driving blog piece I wrote on pharmacogenomic testing, Gene Testing for Meds: Can You Skip the “Trial-and-Error” Rollercoaster? here. ─Janet)
GeneSight (Myriad Genetics): Widely regarded as a leader in psychiatric pharmacogenomics, this test analyzes genetic variations to guide medication choices for depression, anxiety, ADHD, and other psychiatric conditions. [1, 2]
Genomind: Focused on mental health, Genomind provides a professional PGx test for clinicians, often analyzing a broader range of genes (26–35 genes) than some competitors, along with a “Mental Health Map” for consumers. [1, 2]
OneOme (RightMed): Founded in collaboration with Mayo Clinic, the RightMed test covers a wide range of therapeutic areas, including psychiatry, cardiovascular, and pain management, analyzing over 340 medications. [1, 2, 3, 4]
Tempus: A major player utilizing AI to combine DNA testing with large-scale clinical data for oncology and other complex cases. [1]
SelfDecode: A prominent direct-to-consumer (DTC) option that provides PGx insights on over 50 medications without requiring a healthcare provider’s order, specializing in holistic health reports. [1]
Invitae: Offers comprehensive pharmacogenetic panels as part of its wider genetic testing services, providing detailed drug metabolism insights. [1, 2]
Coriell Life Sciences: Known for its comprehensive PGx panels and clinical interpretation, often partnering with employers and health systems. [1, 2]
Key Differences Between Major Players
| Brand/Test | Primary Focus | Best For |
| GeneSight | Psychiatry/Mental Health | Depression/Anxiety medication optimization |
| Genomind | Psychiatric & Mental Health | Comprehensive mental health prescribing guidance |
| OneOme | Multi-Specialty (Wide Coverage) | Broad medication coverage across specialties |
| SelfDecode | DTC/Consumer Health | Independent, user-ordered testing |
| Tempus | AI-driven/Oncology | Complex cases needing large-scale data |
Emerging & Specialized Players
- Neurokaire: Focuses on “brain-in-a-dish” technology (patient-derived neurons) to test medication responses.
- Admera Health: Offers PGxOne Plus, a high-integrity test, along with specialized cardiovascular panels.
- RPh LABS: Provides at-home PGx kits with a focus on comprehensive reporting.
- 23andMe: Currently the primary provider offering direct-to-consumer pharmacogenomic reports for specific medications. [1, 2, 3, 4]
Disclaimer: Pharmacogenomic tests must generally be ordered by a healthcare provider for insurance reimbursement, except for specific consumer-accessible models like SelfDecode or 23andMe. [1, 2]